Huntington's Disease: Nuclear Gatekeepers Under Attack.

Veldman, Matthew B; Yang, X William

Veldman, Matthew B; Yang, X William.

Affiliation

Veldman MB; Center for Neurobehavioral Genetics and Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Yang XW; Center for Neurobehavioral Genetics and Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: xwyang@mednet.ucla.edu.

Neuron ; 94(1): 1-4, 2017 Apr 05.

Article in En | MEDLINE | ID: mdl-28384467

ABSTRACT

ABSTRACT

In this issue of Neuron, Gasset-Rosa et al. (2017) and Grima et al. (2017) describe defects in the nuclear pore complex and impaired nucleocytoplasmic transport in Huntington's disease (HD). The findings suggest that erosion of nuclear gatekeeping function, which is found in normal brain aging, may play an important role in the pathogenesis of multiple neurodegenerative disorders, including HD.

Subject(s)

Brain; Huntington Disease; Aging; Humans; Neurons; Nuclear Proteins

Key words

Huntington's disease; aging; neurodegeneration; nucleocytoplasmic transport

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Huntington Disease Limits: Humans Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2017 Document type: Article Affiliation country: United States Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

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