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Ester-to-amide rearrangement of ethanolamine-derived prodrugs of sobetirome with increased blood-brain barrier penetration.
Ferrara, Skylar J; Meinig, J Matthew; Placzek, Andrew T; Banerji, Tapasree; McTigue, Peter; Hartley, Meredith D; Sanford-Crane, Hannah S; Banerji, Tania; Bourdette, Dennis; Scanlan, Thomas S.
Affiliation
  • Ferrara SJ; Program in Chemical Biology, Department of Physiology & Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States.
  • Meinig JM; Program in Chemical Biology, Department of Physiology & Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States.
  • Placzek AT; Program in Chemical Biology, Department of Physiology & Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States.
  • Banerji T; Program in Chemical Biology, Department of Physiology & Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States.
  • McTigue P; Program in Chemical Biology, Department of Physiology & Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States.
  • Hartley MD; Program in Chemical Biology, Department of Physiology & Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States.
  • Sanford-Crane HS; Program in Chemical Biology, Department of Physiology & Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States.
  • Banerji T; Program in Chemical Biology, Department of Physiology & Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States.
  • Bourdette D; Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States.
  • Scanlan TS; Program in Chemical Biology, Department of Physiology & Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States. Electronic address: scanlant@ohsu.edu.
Bioorg Med Chem ; 25(10): 2743-2753, 2017 05 15.
Article in En | MEDLINE | ID: mdl-28385597
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenols / Blood-Brain Barrier / Ethanolamine / Acetates Type of study: Prognostic_studies Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2017 Document type: Article Affiliation country: United States Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenols / Blood-Brain Barrier / Ethanolamine / Acetates Type of study: Prognostic_studies Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2017 Document type: Article Affiliation country: United States Country of publication: United kingdom