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Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK.
Park, Sung-Jun; Ahmad, Faiyaz; Um, Jee-Hyun; Brown, Alexandra L; Xu, Xihui; Kang, Hyeog; Ke, Hengming; Feng, Xuesong; Ryall, James; Philp, Andrew; Schenk, Simon; Kim, Myung K; Sartorelli, Vittorio; Chung, Jay H.
Affiliation
  • Park SJ; Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Ahmad F; Translational Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Um JH; Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Brown AL; Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Xu X; Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Kang H; Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Ke H; Department of Biochemistry and Biophysics, The University of North Carolina, Chapel Hill, NC 27599, USA.
  • Feng X; Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Ryall J; Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Philp A; School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.
  • Schenk S; Department of Orthopedic Surgery, University of California San Diego, La Jolla, CA 92093, USA.
  • Kim MK; Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Sartorelli V; Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Chung JH; Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: chungj@nhlbi.nih.gov.
EBioMedicine ; 18: 128-138, 2017 Apr.
Article in En | MEDLINE | ID: mdl-28396013
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: AMP-Activated Protein Kinases / Sirtuin 1 / Glucose / Heterocyclic Compounds, 4 or More Rings / Mitochondria Limits: Animals / Humans Language: En Journal: EBioMedicine Year: 2017 Document type: Article Affiliation country: United States Country of publication: Netherlands
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: AMP-Activated Protein Kinases / Sirtuin 1 / Glucose / Heterocyclic Compounds, 4 or More Rings / Mitochondria Limits: Animals / Humans Language: En Journal: EBioMedicine Year: 2017 Document type: Article Affiliation country: United States Country of publication: Netherlands