The emerging role of retromer in neuroprotection.
Curr Opin Cell Biol
; 47: 72-82, 2017 08.
Article
in En
| MEDLINE
| ID: mdl-28399507
ABSTRACT
Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell-cell and cell-matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting station within eukaryotic cells, the endosomal network. Subtle de-regulation of retromer is an emerging theme in the pathoetiology of Parkinson's disease. Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson's disease by interfering with lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Transport
/
Eukaryotic Cells
/
Endosomal Sorting Complexes Required for Transport
/
Neuroprotection
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Cell Biol
Year:
2017
Document type:
Article
Affiliation country:
United kingdom