Importance of Metabolic Adaptations in Francisella Pathogenesis.
Front Cell Infect Microbiol
; 7: 96, 2017.
Article
in En
| MEDLINE
| ID: mdl-28401066
ABSTRACT
Francisella tularensis is a highly infectious Gram-negative bacterium and the causative agent of the zoonotic disease tularemia. This bacterial pathogen can infect a broad variety of animal species and can be transmitted to humans in numerous ways with various clinical outcomes. Although, Francisella possesses the capacity to infect numerous mammalian cell types, the macrophage constitutes the main intracellular niche, used for in vivo bacterial dissemination. To survive and multiply within infected macrophages, Francisella must imperatively escape from the phagosomal compartment. In the cytosol, the bacterium needs to control the host innate immune response and adapt its metabolism to this nutrient-restricted niche. Our laboratory has shown that intracellular Francisella mainly relied on host amino acid as major gluconeogenic substrates and provided evidence that the host metabolism was also modified upon Francisella infection. We will review here our current understanding of how Francisella copes with the available nutrient sources provided by the host cell during the course of infection.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tularemia
/
Adaptation, Physiological
/
Host-Pathogen Interactions
/
Francisella
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Front Cell Infect Microbiol
Year:
2017
Document type:
Article
Affiliation country:
France