Current and future role of genetic screening in gynecologic malignancies.

Ring, Kari L; Garcia, Christine; Thomas, Martha H; Modesitt, Susan C

Current and future role of genetic screening in gynecologic malignancies.

Ring, Kari L; Garcia, Christine; Thomas, Martha H; Modesitt, Susan C.

Affiliation

Ring KL; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Virginia Health System, Charlottesville, VA. Electronic address: KEL7J@hscmail.mcc.virginia.edu.
Garcia C; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Virginia Health System, Charlottesville, VA.
Thomas MH; Division of Cancer Genetics, University of Virginia Health System, Charlottesville, VA.
Modesitt SC; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Virginia Health System, Charlottesville, VA.

Am J Obstet Gynecol ; 217(5): 512-521, 2017 11.

Article in En | MEDLINE | ID: mdl-28411145

Subject(s)

Genital Neoplasms, Female/diagnosis; Neoplastic Syndromes, Hereditary/diagnosis; AMP-Activated Protein Kinase Kinases; DNA Mismatch Repair/genetics; DNA Polymerase III/genetics; DNA-Binding Proteins/genetics; Epithelial Cell Adhesion Molecule/genetics; Fanconi Anemia Complementation Group Proteins/genetics; Female; Genes, BRCA1; Genes, BRCA2; Genetic Predisposition to Disease; Genetic Testing; Genital Neoplasms, Female/genetics; Hamartoma Syndrome, Multiple/diagnosis; Hamartoma Syndrome, Multiple/genetics; Hereditary Breast and Ovarian Cancer Syndrome/diagnosis; Hereditary Breast and Ovarian Cancer Syndrome/genetics; Humans; Li-Fraumeni Syndrome/diagnosis; Li-Fraumeni Syndrome/genetics; Lynch Syndrome II/diagnosis; Lynch Syndrome II/genetics; Mismatch Repair Endonuclease PMS2/genetics; MutL Protein Homolog 1/genetics; MutS Homolog 2 Protein/genetics; Neoplastic Syndromes, Hereditary/genetics; PTEN Phosphohydrolase/genetics; Peutz-Jeghers Syndrome/diagnosis; Peutz-Jeghers Syndrome/genetics; Protein Serine-Threonine Kinases/genetics; RNA Helicases/genetics; Tumor Suppressor Protein p53/genetics

Key words

BRCA; Lynch syndrome; cervical cancer; endometrial cancer; hereditary cancer; high risk; ovarian cancer; risk reduction; screening

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Syndromes, Hereditary / Genital Neoplasms, Female Type of study: Diagnostic_studies / Guideline / Prognostic_studies / Screening_studies Language: En Journal: Am J Obstet Gynecol Year: 2017 Document type: Article Country of publication: United States

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