An overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation.
Exp Mol Med
; 49(4): e320, 2017 04 21.
Article
in En
| MEDLINE
| ID: mdl-28428631
ABSTRACT
The complement system is an innate immune defense machinery comprising components that deploy rapid immune responses and provide efficient protection against foreign invaders and unwanted host elements. The complement system is activated upon recognition of pathogenic microorganisms or altered self-cells by exclusive pattern recognition molecules (PRMs), such as collectins, ficolins and pentraxins. Recent accumulating evidence shows that the different classes of effector PRMs build up a co-operative network and exert synergistic effects on complement activation. In this review, we describe our updated view of the crosstalk between previously unlinked PRMs in complement activation and the potential pathogenic effects during infection and inflammation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
C-Reactive Protein
/
Complement Activation
/
Collectins
/
Immunity, Innate
/
Lectins
Limits:
Animals
/
Humans
Language:
En
Journal:
Exp Mol Med
Journal subject:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Year:
2017
Document type:
Article
Affiliation country:
Denmark