Your browser doesn't support javascript.
loading
A specific nanobody prevents amyloidogenesis of D76N ß2-microglobulin in vitro and modifies its tissue distribution in vivo.
Raimondi, Sara; Porcari, Riccardo; Mangione, P Patrizia; Verona, Guglielmo; Marcoux, Julien; Giorgetti, Sofia; Taylor, Graham W; Ellmerich, Stephan; Ballico, Maurizio; Zanini, Stefano; Pardon, Els; Al-Shawi, Raya; Simons, J Paul; Corazza, Alessandra; Fogolari, Federico; Leri, Manuela; Stefani, Massimo; Bucciantini, Monica; Gillmore, Julian D; Hawkins, Philip N; Valli, Maurizia; Stoppini, Monica; Robinson, Carol V; Steyaert, Jan; Esposito, Gennaro; Bellotti, Vittorio.
Affiliation
  • Raimondi S; Department of Molecular Medicine, Institute of Biochemistry, University of Pavia, Via Taramelli 3b, 27100 Pavia, Italy.
  • Porcari R; Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, UK.
  • Mangione PP; Department of Molecular Medicine, Institute of Biochemistry, University of Pavia, Via Taramelli 3b, 27100 Pavia, Italy.
  • Verona G; Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, UK.
  • Marcoux J; Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, UK.
  • Giorgetti S; Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.
  • Taylor GW; Department of Molecular Medicine, Institute of Biochemistry, University of Pavia, Via Taramelli 3b, 27100 Pavia, Italy.
  • Ellmerich S; Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, UK.
  • Ballico M; Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, UK.
  • Zanini S; Science and Math Division, New York University at Abu Dhabi, Abu Dhabi, UAE.
  • Pardon E; Science and Math Division, New York University at Abu Dhabi, Abu Dhabi, UAE.
  • Al-Shawi R; Structural Biology Research Centre, VIB, Pleinlaan 2, 1050, Brussel, Belgium.
  • Simons JP; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussel, Belgium.
  • Corazza A; Centre for Biomedical Science, Division of Medicine, University College London, London NW3 2PF, UK.
  • Fogolari F; Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, UK.
  • Leri M; Department of Medical and Biological Sciences (DSMB), University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy.
  • Stefani M; Istituto Nazionale Biostrutture e Biosistemi, Viale Medaglie d'Oro 305, 00136 Roma, Italy.
  • Bucciantini M; Istituto Nazionale Biostrutture e Biosistemi, Viale Medaglie d'Oro 305, 00136 Roma, Italy.
  • Gillmore JD; Department of Mathematics, Computer Science and Physics, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy.
  • Hawkins PN; Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence, Viale Morgagni 50, 50134 Florence, Italy.
  • Valli M; Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence, Viale Morgagni 50, 50134 Florence, Italy.
  • Stoppini M; Research Centre for Molecular Basis of Neurodegeneration, 50134 Florence, Italy.
  • Robinson CV; Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence, Viale Morgagni 50, 50134 Florence, Italy.
  • Steyaert J; Research Centre for Molecular Basis of Neurodegeneration, 50134 Florence, Italy.
  • Esposito G; National Amyloidosis Centre, University College London, London NW3 2PF, UK.
  • Bellotti V; National Amyloidosis Centre, University College London, London NW3 2PF, UK.
Sci Rep ; 7: 46711, 2017 04 21.
Article in En | MEDLINE | ID: mdl-28429761
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Beta 2-Microglobulin / Single-Domain Antibodies / Amyloidosis Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2017 Document type: Article Affiliation country: Italy
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Beta 2-Microglobulin / Single-Domain Antibodies / Amyloidosis Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2017 Document type: Article Affiliation country: Italy