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Stimulatory effect of desipramine on lung metastases of adenocarcinoma MADB 106 in stress highly-sensitive and stress non-reactive rats.
Grygier, Beata; Kubera, Marta; Wrona, Danuta; Roman, Adam; Basta-Kaim, Agnieszka; Gruca, Piotr; Papp, Mariusz; Rogoz, Zofia; Leskiewicz, Monika; Budziszewska, Boguslawa; Regulska, Magdalena; Korzeniak, Barbara; Curzytek, Katarzyna; Glombik, Katarzyna; Slusarczyk, Joanna; Maes, Michael; Lason, Wladyslaw.
Affiliation
  • Grygier B; Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL 31-343 Krakow, Poland; Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 7 Gronostajowa St., 30-387 Krakow, Poland.
  • Kubera M; Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL 31-343 Krakow, Poland. Electronic address: kubera@if-pan.krakow.pl.
  • Wrona D; Department of Animal and Human Physiology, University of Gdansk, 59 Wita Stwosza Street, 80-308 Gdansk, Poland.
  • Roman A; Department of Brain Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL 31-343 Krakow, Poland.
  • Basta-Kaim A; Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL 31-343 Krakow, Poland.
  • Gruca P; Behavioural Pharmacology Laboratory, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL 31-343 Krakow, Poland.
  • Papp M; Behavioural Pharmacology Laboratory, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL 31-343 Krakow, Poland.
  • Rogoz Z; Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343 Krakow, Poland.
  • Leskiewicz M; Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL 31-343 Krakow, Poland.
  • Budziszewska B; Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL 31-343 Krakow, Poland.
  • Regulska M; Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL 31-343 Krakow, Poland.
  • Korzeniak B; Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL 31-343 Krakow, Poland.
  • Curzytek K; Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL 31-343 Krakow, Poland.
  • Glombik K; Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL 31-343 Krakow, Poland.
  • Slusarczyk J; Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL 31-343 Krakow, Poland.
  • Maes M; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, 10330 Bangkok, Thailand.
  • Lason W; Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL 31-343 Krakow, Poland.
Prog Neuropsychopharmacol Biol Psychiatry ; 80(Pt C): 279-290, 2018 Jan 03.
Article in En | MEDLINE | ID: mdl-28433460
The effect of antidepressant drugs on tumor progress is very poorly recognized. The aim of the present study was to examine the effect of individual reactivity to stress and 24-day desipramine (DES) administration on the metastatic colonization of adenocarcinoma MADB 106 cells in the lungs of Wistar rats. Wistar rats were subjected to stress procedure according to the chronic mild stress (CMS) model of depression for two weeks and stress highly-sensitive (SHS) and stress non-reactive (SNR) rats were selected. SHS rats were more prone to cancer metastasis than SNR ones and chronic DES treatment further increased the number of lung metastases by 59% and 50% in comparison to vehicle-treated appropriate control rats. The increase in lung metastases was connected with DES-induced skew macrophage activity towards M2 functional phenotype in SHS and SNR rats. Moreover, during 24h after DES injection in healthy rats, the decreased number of TCD8+ and B cells in SHS and SNR rats as well as NK cell cytotoxic activity in SNR rats could be attributed to the lowered capacity to defend against cancer metastasis observed in chronic DES treated and tumor injected rats.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Psychological / Adenocarcinoma / Desipramine / Lung Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Prog Neuropsychopharmacol Biol Psychiatry Year: 2018 Document type: Article Affiliation country: Poland Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Psychological / Adenocarcinoma / Desipramine / Lung Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Prog Neuropsychopharmacol Biol Psychiatry Year: 2018 Document type: Article Affiliation country: Poland Country of publication: United kingdom