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The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.
Yip, Bon Ham; Steeples, Violetta; Repapi, Emmanouela; Armstrong, Richard N; Llorian, Miriam; Roy, Swagata; Shaw, Jacqueline; Dolatshad, Hamid; Taylor, Stephen; Verma, Amit; Bartenstein, Matthias; Vyas, Paresh; Cross, Nicholas Cp; Malcovati, Luca; Cazzola, Mario; Hellström-Lindberg, Eva; Ogawa, Seishi; Smith, Christopher Wj; Pellagatti, Andrea; Boultwood, Jacqueline.
Affiliation
  • Yip BH; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and BRC Blood Theme, National Institute for Health Research (NIHR) Oxford Biomedical Centre, Oxford University Hospital, Oxford, United Kingdom.
  • Steeples V; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and BRC Blood Theme, National Institute for Health Research (NIHR) Oxford Biomedical Centre, Oxford University Hospital, Oxford, United Kingdom.
  • Repapi E; The Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
  • Armstrong RN; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and BRC Blood Theme, National Institute for Health Research (NIHR) Oxford Biomedical Centre, Oxford University Hospital, Oxford, United Kingdom.
  • Llorian M; Department of Biochemistry, Downing Site, University of Cambridge, Cambridge, United Kingdom.
  • Roy S; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and BRC Blood Theme, National Institute for Health Research (NIHR) Oxford Biomedical Centre, Oxford University Hospital, Oxford, United Kingdom.
  • Shaw J; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and BRC Blood Theme, National Institute for Health Research (NIHR) Oxford Biomedical Centre, Oxford University Hospital, Oxford, United Kingdom.
  • Dolatshad H; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and BRC Blood Theme, National Institute for Health Research (NIHR) Oxford Biomedical Centre, Oxford University Hospital, Oxford, United Kingdom.
  • Taylor S; The Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
  • Verma A; Albert Einstein College of Medicine, Bronx, New York, USA.
  • Bartenstein M; Albert Einstein College of Medicine, Bronx, New York, USA.
  • Vyas P; Medical Research Council, Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, and Department of Hematology, Oxford University Hospital National Health Service Trust, Oxford, United Kingdom.
  • Cross NC; Faculty of Medicine, University of Southampton, Southampton, and National Genetics Reference Laboratory (Wessex), Salisbury, United Kingdom.
  • Malcovati L; Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
  • Cazzola M; Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
  • Hellström-Lindberg E; Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.
  • Ogawa S; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.
  • Smith CW; Department of Biochemistry, Downing Site, University of Cambridge, Cambridge, United Kingdom.
  • Pellagatti A; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and BRC Blood Theme, National Institute for Health Research (NIHR) Oxford Biomedical Centre, Oxford University Hospital, Oxford, United Kingdom.
  • Boultwood J; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and BRC Blood Theme, National Institute for Health Research (NIHR) Oxford Biomedical Centre, Oxford University Hospital, Oxford, United Kingdom.
J Clin Invest ; 127(6): 2206-2221, 2017 Jun 01.
Article in En | MEDLINE | ID: mdl-28436936
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myelodysplastic Syndromes / Splicing Factor U2AF Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: J Clin Invest Year: 2017 Document type: Article Affiliation country: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myelodysplastic Syndromes / Splicing Factor U2AF Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: J Clin Invest Year: 2017 Document type: Article Affiliation country: United kingdom