Ocular non-P450 oxidative, reductive, hydrolytic, and conjugative drug metabolizing enzymes.

Argikar, Upendra A; Dumouchel, Jennifer L; Dunne, Christine E; Bushee, Andrea J

Argikar, Upendra A; Dumouchel, Jennifer L; Dunne, Christine E; Bushee, Andrea J.

Affiliation

Argikar UA; a Analytical Sciences and Imaging , Novartis Institutes for Biomedical Research, Inc , Cambridge , MA , USA.
Dumouchel JL; a Analytical Sciences and Imaging , Novartis Institutes for Biomedical Research, Inc , Cambridge , MA , USA.
Dunne CE; b Department of Chemistry , Colorado State University , Fort Collins , CO , USA.
Bushee AJ; c GreenBanana SEO , Beverly , MA , USA.

Drug Metab Rev ; 49(3): 372-394, 2017 08.

Article in En | MEDLINE | ID: mdl-28438049

Subject(s)

Eye/enzymology; Xenobiotics/metabolism; Animals; Cytochrome P-450 Enzyme System/metabolism; Humans; Oxidation-Reduction; Xenobiotics/pharmacokinetics

Key words

Ocular metabolism; drug metabolizing enzymes; extrahepatic metabolism; eye; ocular disposition; ophthalmic barriers; ophthalmic drugs

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Xenobiotics / Eye Limits: Animals / Humans Language: En Journal: Drug Metab Rev Year: 2017 Document type: Article Affiliation country: United States Country of publication: United kingdom

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