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Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion.
He, Shenghui; Roberts, Patrick J; Sorrentino, Jessica A; Bisi, John E; Storrie-White, Hannah; Tiessen, Renger G; Makhuli, Karenann M; Wargin, William A; Tadema, Henko; van Hoogdalem, Ewoud-Jan; Strum, Jay C; Malik, Rajesh; Sharpless, Norman E.
Affiliation
  • He S; Departments of Genetics and Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7295, USA.
  • Roberts PJ; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7295, USA.
  • Sorrentino JA; G1 Therapeutics Inc., Research Triangle Park, NC 27709, USA.
  • Bisi JE; G1 Therapeutics Inc., Research Triangle Park, NC 27709, USA.
  • Storrie-White H; G1 Therapeutics Inc., Research Triangle Park, NC 27709, USA.
  • Tiessen RG; G1 Therapeutics Inc., Research Triangle Park, NC 27709, USA.
  • Makhuli KM; PRA Health Sciences, P.O. Box 200, 9470 AE Zuidlaren, Netherlands.
  • Wargin WA; G1 Therapeutics Inc., Research Triangle Park, NC 27709, USA.
  • Tadema H; Nuventra Pharma Sciences, Research Triangle Park, NC 27713, USA.
  • van Hoogdalem EJ; PRA Health Sciences, P.O. Box 200, 9470 AE Zuidlaren, Netherlands.
  • Strum JC; PRA Health Sciences, P.O. Box 200, 9470 AE Zuidlaren, Netherlands.
  • Malik R; G1 Therapeutics Inc., Research Triangle Park, NC 27709, USA.
  • Sharpless NE; G1 Therapeutics Inc., Research Triangle Park, NC 27709, USA.
Sci Transl Med ; 9(387)2017 04 26.
Article in En | MEDLINE | ID: mdl-28446688
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States