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Mild, Redox-Neutral Formylation of Aryl Chlorides through the Photocatalytic Generation of Chlorine Radicals.
Nielsen, Matthew K; Shields, Benjamin J; Liu, Junyi; Williams, Michael J; Zacuto, Michael J; Doyle, Abigail G.
Affiliation
  • Nielsen MK; Department of Chemistry, Princeton University, 120 Washington Road, Princeton, NJ, 08544, USA.
  • Shields BJ; Department of Chemistry, Princeton University, 120 Washington Road, Princeton, NJ, 08544, USA.
  • Liu J; Department of Chemistry, Princeton University, 120 Washington Road, Princeton, NJ, 08544, USA.
  • Williams MJ; Drug Substance Development, Celgene Corporation, 556 Morris Ave., Summit, NJ, 07901, USA.
  • Zacuto MJ; Drug Substance Development, Celgene Corporation, 556 Morris Ave., Summit, NJ, 07901, USA.
  • Doyle AG; Department of Chemistry, Princeton University, 120 Washington Road, Princeton, NJ, 08544, USA.
Angew Chem Int Ed Engl ; 56(25): 7191-7194, 2017 06 12.
Article in En | MEDLINE | ID: mdl-28471521
ABSTRACT
We report a redox-neutral formylation of aryl chlorides that proceeds through selective 2-functionalization of 1,3-dioxolane through nickel and photoredox catalysis. This scalable benchtop approach provides a distinct advantage over traditional reductive carbonylation in that no carbon monoxide, pressurized gas, or stoichiometric reductant is employed. The mild conditions give unprecedented scope from abundant and complex aryl chloride starting materials.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chlorides / Chlorine / Photochemical Processes / Free Radicals Language: En Journal: Angew Chem Int Ed Engl Year: 2017 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chlorides / Chlorine / Photochemical Processes / Free Radicals Language: En Journal: Angew Chem Int Ed Engl Year: 2017 Document type: Article Affiliation country: United States