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Repeat application of microneedles does not alter skin appearance or barrier function and causes no measurable disturbance of serum biomarkers of infection, inflammation or immunity in mice in vivo.
Vicente-Perez, Eva M; Larrañeta, Eneko; McCrudden, Maelíosa T C; Kissenpfennig, Adrien; Hegarty, Shauna; McCarthy, Helen O; Donnelly, Ryan F.
Affiliation
  • Vicente-Perez EM; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
  • Larrañeta E; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
  • McCrudden MTC; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
  • Kissenpfennig A; The Wellcome-Wolfson Building, Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
  • Hegarty S; Royal Victoria Hospital, 274 Grosvenor Road, Belfast BT12 6BA, UK.
  • McCarthy HO; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
  • Donnelly RF; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK. Electronic address: r.donnelly@qub.ac.uk.
Eur J Pharm Biopharm ; 117: 400-407, 2017 Aug.
Article in En | MEDLINE | ID: mdl-28478160
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Water Loss, Insensible / Immunity, Cellular / Microinjections / Needles Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Eur J Pharm Biopharm Journal subject: FARMACIA / FARMACOLOGIA Year: 2017 Document type: Article Affiliation country: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Water Loss, Insensible / Immunity, Cellular / Microinjections / Needles Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Eur J Pharm Biopharm Journal subject: FARMACIA / FARMACOLOGIA Year: 2017 Document type: Article Affiliation country: United kingdom