Behavioral study of a rat model of migraine induced by CGRP.
Neurosci Lett
; 651: 134-139, 2017 06 09.
Article
in En
| MEDLINE
| ID: mdl-28479104
Migraine is a debilitating disorder characterized by recurrent headache arising from neurovascular dysfunction. Despite recent progress in migraine research, the exact mechanisms underpinning migraine are poorly understood. Furthermore, it is difficult to develop an animal model of migraine that resembles all symptoms of patients. In this study, we established a novel animal model of migraine induced by epidural injection of calcitonin gene-related peptide (CGRP), and examined climbing hutch behavior, facial-grooming behavior, body-grooming behavior, freezing behavior, resting behavior, and ipsilateral hindpaw facial grooming behavior of rats following CGRP injection. CGRP significantly reduced climbing hutch behavior, and face-grooming behavior, and increased immobile behavior. We also found that the P15 and P85 percentile range of behavioral data exhibited a high positive rate (83.3%) for establishing the model with less false positive rate. Our results verified that the rat model of migraine induced by CGRP featured many behaviors of migraine patients demonstrated during migraine attacks. Our findings suggest that this new model can be a useful tool for understanding the pathophysiology of migraine and studying novel therapeutic strategies for the treatment of migraine.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Behavior, Animal
/
Calcitonin Gene-Related Peptide
/
Disease Models, Animal
/
Migraine Disorders
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Neurosci Lett
Year:
2017
Document type:
Article
Affiliation country:
China
Country of publication:
Ireland