Fibrin-Targeted and H<sub>2</sub>O<sub>2</sub>-Responsive Nanoparticles as a Theranostics for Thrombosed Vessels.

Kang, Changsun; Gwon, Sian; Song, ChulGyu; Kang, Peter M; Park, Seong-Cheol; Jeon, Jongho; Hwang, Do Won; Lee, Dongwon

Fibrin-Targeted and H₂O₂-Responsive Nanoparticles as a Theranostics for Thrombosed Vessels.

Kang, Changsun; Gwon, Sian; Song, ChulGyu; Kang, Peter M; Park, Seong-Cheol; Jeon, Jongho; Hwang, Do Won; Lee, Dongwon.

Affiliation

Kang PM; Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts 02215, United States.
Park SC; Department of Polymer Engineering, Sunchon National University , Sunchon, Chonnam 540-950, Korea.
Jeon J; Advanced Radiation Technology Institute, Atomic Energy Research Institute , Jeongeup, Chonbuk 580-185, Korea.
Hwang DW; Department of Nuclear Medicine, Seoul National University College of Medicine , Seoul 151-742, Korea.

ACS Nano ; 11(6): 6194-6203, 2017 06 27.

Article in En | MEDLINE | ID: mdl-28481519

Subject(s)

Carotid Artery Thrombosis/diagnostic imaging; Carotid Artery Thrombosis/drug therapy; Fibrin/metabolism; Fibrinolytic Agents/therapeutic use; Fluorescent Dyes/chemistry; Hydrogen Peroxide/metabolism; Nanoparticles/chemistry; Animals; Boronic Acids/chemistry; CD40 Ligand/metabolism; Carotid Artery Thrombosis/chemically induced; Carotid Artery Thrombosis/metabolism; Cell Survival/drug effects; Chlorides; Drug Carriers; Drug Liberation; Endothelial Cells/cytology; Endothelial Cells/drug effects; Ferric Compounds; Fibrinolytic Agents/chemistry; Humans; Lipopeptides/chemistry; Mice; Optical Imaging; Polymers; RAW 264.7 Cells; Theranostic Nanomedicine; Thrombosis/diagnostic imaging; Thrombosis/drug therapy; Thrombosis/metabolism; Tirofiban/chemistry; Tirofiban/therapeutic use; Tumor Necrosis Factor-alpha/metabolism

Key words

antiplatelet; hydrogen peroxide; nanomedicine; theranostics; thrombosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fibrin / Carotid Artery Thrombosis / Nanoparticles / Fibrinolytic Agents / Fluorescent Dyes / Hydrogen Peroxide Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: ACS Nano Year: 2017 Document type: Article Country of publication: United States

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