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Atomically precise organomimetic cluster nanomolecules assembled via perfluoroaryl-thiol SNAr chemistry.
Qian, Elaine A; Wixtrom, Alex I; Axtell, Jonathan C; Saebi, Azin; Jung, Dahee; Rehak, Pavel; Han, Yanxiao; Moully, Elamar Hakim; Mosallaei, Daniel; Chow, Sylvia; Messina, Marco S; Wang, Jing Yang; Royappa, A Timothy; Rheingold, Arnold L; Maynard, Heather D; Král, Petr; Spokoyny, Alexander M.
Affiliation
  • Qian EA; Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
  • Wixtrom AI; Department of Bioengineering, University of California, Los Angeles, California 90095, USA.
  • Axtell JC; California NanoSystems Institute, University of California, Los Angeles, California 90095, USA.
  • Saebi A; Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
  • Jung D; Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
  • Rehak P; Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
  • Han Y; Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
  • Moully EH; California NanoSystems Institute, University of California, Los Angeles, California 90095, USA.
  • Mosallaei D; Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607, USA.
  • Chow S; Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607, USA.
  • Messina MS; Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
  • Wang JY; Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
  • Royappa AT; Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
  • Rheingold AL; Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
  • Maynard HD; California NanoSystems Institute, University of California, Los Angeles, California 90095, USA.
  • Král P; Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
  • Spokoyny AM; Department of Chemistry, University of West Florida, Pensacola, Florida 32514, USA.
Nat Chem ; 9(4): 333-340, 2017 04.
Article in En | MEDLINE | ID: mdl-28485398
ABSTRACT
The majority of biomolecules are intrinsically atomically precise, an important characteristic that enables rational engineering of their recognition and binding properties. However, imparting a similar precision to hybrid nanoparticles has been challenging because of the inherent limitations of existing chemical methods and building blocks. Here we report a new approach to form atomically precise and highly tunable hybrid nanomolecules with well-defined three-dimensionality. Perfunctionalization of atomically precise clusters with pentafluoroaryl-terminated linkers produces size-tunable rigid cluster nanomolecules. These species are amenable to facile modification with a variety of thiol-containing molecules and macromolecules. Assembly proceeds at room temperature within hours under mild conditions, and the resulting nanomolecules exhibit high stabilities because of their full covalency. We further demonstrate how these nanomolecules grafted with saccharides can exhibit dramatically improved binding affinity towards a protein. Ultimately, the developed strategy allows the rapid generation of precise molecular assemblies to investigate multivalent interactions.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Nat Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Nat Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: United States