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Differential proteome profile in ischemic heart disease: Prognostic value in chronic angina versus myocardial infarction. A proof of concept.
Scebba, Francesca; Papale, Massimo; Rocchiccioli, Silvia; Ucciferri, Nadia; Bigazzi, Federico; Sampietro, Tiziana; Carpeggiani, Clara; L'Abbate, Antonio; Coceani, Flavio; Angeloni, Debora.
Affiliation
  • Scebba F; Institute of Life Sciences, Scuola Superiore Sant'Anna, P.zza Martiri della Libertà 33, 56127 Pisa, Italy. Electronic address: f.scebba@santannapisa.it.
  • Papale M; Molecular Medicine Centre, Department of Surgery and Medical Sciences, University of Foggia, Viale Pinto 1, 71122 Foggia, Italy. Electronic address: m.papale@unifg.it.
  • Rocchiccioli S; Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Via Moruzzi 1, 56124 Pisa, Italy. Electronic address: silvia.rocchiccioli@ifc.cnr.it.
  • Ucciferri N; Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Via Moruzzi 1, 56124 Pisa, Italy. Electronic address: nadia.ucciferri@ifc.cnr.it.
  • Bigazzi F; Dyslipidemias & Atherosclerosis Laboratory, Fondazione Toscana Gabriele Monasterio, Via Moruzzi 1, 56124 Pisa, Italy. Electronic address: federicobigazzi@ftgm.it.
  • Sampietro T; Dyslipidemias & Atherosclerosis Laboratory, Fondazione Toscana Gabriele Monasterio, Via Moruzzi 1, 56124 Pisa, Italy. Electronic address: tiziana.sampietro@ftgm.it.
  • Carpeggiani C; Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Via Moruzzi 1, 56124 Pisa, Italy. Electronic address: clara@ifc.cnr.it.
  • L'Abbate A; Institute of Life Sciences, Scuola Superiore Sant'Anna, P.zza Martiri della Libertà 33, 56127 Pisa, Italy; Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Via Moruzzi 1, 56124 Pisa, Italy. Electronic address: segrlabb@ifc.cnr.it.
  • Coceani F; Institute of Life Sciences, Scuola Superiore Sant'Anna, P.zza Martiri della Libertà 33, 56127 Pisa, Italy. Electronic address: coceani@santannapisa.it.
  • Angeloni D; Institute of Life Sciences, Scuola Superiore Sant'Anna, P.zza Martiri della Libertà 33, 56127 Pisa, Italy; Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Via Moruzzi 1, 56124 Pisa, Italy. Electronic address: d.angeloni@santannapisa.it.
Clin Chim Acta ; 471: 68-75, 2017 Aug.
Article in En | MEDLINE | ID: mdl-28501389
ABSTRACT
The initial clinical manifestation of ischemic heart disease (IHD) i.e. unheralded myocardial infarction (MI) versus chronic angina pectoris (AP) is statistically associated with adverse or mild disease progression respectively in the long-term follow-up. Here, we subjected AP and MI patients to blood proteomic analysis by Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF-MS) in order to investigate putative new prognostic biomarkers of IHD manifestation. We found several differentially expressed peaks but four of them (4176, 4475, 14,158m/z and 8922m/z for AP and MI, respectively) were most reliable. Two of them were identified; 14,158m/z peak was the double-charged form of Apolipoprotein A-I and its vasoprotective action accords with prominence in AP. The 4176m/z peak was related to FAM83C protein, while neither the 4475m/z peak nor the MI-linked 8922m/z peak could be identified. We conclude that SELDI-TOF-MS analysis may yield a panel of molecular signals able to retrospectively classify patients according to their clinical and molecular features, exploitable for predicting the natural course of IHD.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteomics / Angina, Stable / Myocardial Infarction Type of study: Prognostic_studies Aspects: Patient_preference Limits: Female / Humans / Male / Middle aged Language: En Journal: Clin Chim Acta Year: 2017 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteomics / Angina, Stable / Myocardial Infarction Type of study: Prognostic_studies Aspects: Patient_preference Limits: Female / Humans / Male / Middle aged Language: En Journal: Clin Chim Acta Year: 2017 Document type: Article