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UGT1A1 polymorphisms with irinotecan-induced toxicities and treatment outcome in Asians with Lung Cancer: a meta-analysis.
Chen, Xuewei; Liu, Liping; Guo, Zhihua; Liang, Wenhua; He, Jiaxi; Huang, Liyan; Deng, Qiuhua; Tang, Hailing; Pan, Hui; Guo, Minzhang; Liu, Yang; He, Qihua; He, Jianxing.
Affiliation
  • Chen X; Department of Thoracic Surgery, Guangzhou Institute of Respiratory Disease and State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, No 151, Yanjiang Rd, Guangzhou, 510120, Guangdong, People's Republic of China.
  • Liu L; The Translational Medicine Laboratory, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Guo Z; Key Cite of National Clinical Research Center for Respiratory Disease, Guangzhou, People's Republic of China.
  • Liang W; The Translational Medicine Laboratory, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
  • He J; Key Cite of National Clinical Research Center for Respiratory Disease, Guangzhou, People's Republic of China.
  • Huang L; Department of Thoracic Surgery, Guangzhou Institute of Respiratory Disease and State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, No 151, Yanjiang Rd, Guangzhou, 510120, Guangdong, People's Republic of China.
  • Deng Q; Key Cite of National Clinical Research Center for Respiratory Disease, Guangzhou, People's Republic of China.
  • Tang H; Department of Thoracic Surgery, Guangzhou Institute of Respiratory Disease and State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, No 151, Yanjiang Rd, Guangzhou, 510120, Guangdong, People's Republic of China.
  • Pan H; Key Cite of National Clinical Research Center for Respiratory Disease, Guangzhou, People's Republic of China.
  • Guo M; Department of Thoracic Surgery, Guangzhou Institute of Respiratory Disease and State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, No 151, Yanjiang Rd, Guangzhou, 510120, Guangdong, People's Republic of China.
  • Liu Y; Key Cite of National Clinical Research Center for Respiratory Disease, Guangzhou, People's Republic of China.
  • He Q; The Translational Medicine Laboratory, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
  • He J; Key Cite of National Clinical Research Center for Respiratory Disease, Guangzhou, People's Republic of China.
Cancer Chemother Pharmacol ; 79(6): 1109-1117, 2017 Jun.
Article in En | MEDLINE | ID: mdl-28502040
Previous studies of irinotecan pharmacogenetics have shown that the UGT1A1*28 polymorphism has an effect on irinotecan (IRI)-induced toxicities in Caucasians. Yet compared with the UGT1A1*6 mutation, the UGT1A1*28 occurs at a much lower frequency in the Asians. Whether UGT1A1*6 and UGT1A1*28 are associated with IRI-induced neutropenia, diarrhea and IRI-based chemotherapy tumor response (TR) in Asians with lung cancer remains controversial. In this meta-analysis, we found a higher risk of neutropenia and diarrhea with IRI-based chemotherapy in Asians with lung cancer carrying the UGT1A1*6 polymorphism. However, UGT1A1*28 showed a weak correlation with diarrhea, but no significant correlation with neutropenia. Neither UGT1A1*6 nor UGT1A1*28 is associated with IRI-based chemotherapy TR. These data suggest that the UGT1A1*28 polymorphism may not be a suitable biomarker to predict IRI-induced toxicities and chemotherapy TR in Asians, while UGT1A*6 polymorphism is associated with a higher risk of IRI-induced neutropenia and diarrhea, but not IRI-based chemotherapy TR.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Camptothecin / Glucuronosyltransferase / Asian People / Lung Neoplasms / Antineoplastic Agents, Phytogenic Type of study: Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Cancer Chemother Pharmacol Year: 2017 Document type: Article Country of publication: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Camptothecin / Glucuronosyltransferase / Asian People / Lung Neoplasms / Antineoplastic Agents, Phytogenic Type of study: Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Cancer Chemother Pharmacol Year: 2017 Document type: Article Country of publication: Germany