A quantitative approach to understanding vertebrate limb morphogenesis at the macroscopic tissue level.
Curr Opin Genet Dev
; 45: 108-114, 2017 Aug.
Article
in En
| MEDLINE
| ID: mdl-28502890
ABSTRACT
To understand organ morphogenetic mechanisms, it is essential to clarify how spatiotemporally-regulated molecular/cellular dynamics causes physical tissue deformation. In the case of vertebrate limb development, while some of the genes and oriented cell behaviors underlying morphogenesis have been revealed, tissue deformation dynamics remains incompletely understood. We here introduce our recent work on the reconstruction of tissue deformation dynamics in chick limb development from cell lineage tracing data. This analysis has revealed globally-aligned anisotropic tissue deformation along the proximo-distal axis not only in the distal region but also in the whole limb bud. This result points to a need, as a future challenge, to find oriented molecular/cellular behaviors for realizing the observed anisotropic tissue deformation in both proximal and distal regions, which will lead to systems understanding of limb morphogenesis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vertebrates
/
Limb Buds
/
Organogenesis
Limits:
Animals
Language:
En
Journal:
Curr Opin Genet Dev
Journal subject:
GENETICA
Year:
2017
Document type:
Article