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PET Imaging of 18F-FDG, 11C-methionine, 11C-flumazenil, and 11C-4DST in Progressive Multifocal Leukoencephalopathy.
Ishibashi, Kenji; Miura, Yoshiharu; Matsumura, Ken; Kanemasa, Yusuke; Nakamichi, Kazuo; Saijo, Masayuki; Toyohara, Jun; Ishii, Kenji.
Affiliation
  • Ishibashi K; Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Japan.
  • Miura Y; Department of Neurology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Japan.
  • Matsumura K; Department of Neurology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Japan.
  • Kanemasa Y; Department of Neurology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Japan.
  • Nakamichi K; Department of Medical Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Japan.
  • Saijo M; Department of Virology 1, National Institute of Infectious Diseases, Japan.
  • Toyohara J; Department of Virology 1, National Institute of Infectious Diseases, Japan.
  • Ishii K; Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Japan.
Intern Med ; 56(10): 1219-1223, 2017.
Article in En | MEDLINE | ID: mdl-28502940
ABSTRACT
The use of positron emission tomography (PET) imaging in progressive multifocal leukoencephalopathy (PML) has rarely been reported. We herein report a set of PET images in a 63-year-old patient with PML. In PML lesions, the uptake of 18F-fluorodeoxyglucose, 11C-methionine, 11C-flumazenil, and [methyl-11C]4'-thiothymidine was decreased, increased, decreased, and unchanged, respectively. These results suggest that glucose metabolism decreased, protein synthesis increased, neuronal integrity decreased, and the DNA synthesis and cellular proliferation of host cells were not activated in PML lesions. These results may reflect very little infiltration by inflammatory cells and active infection with JC virus in this case.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flumazenil / Leukoencephalopathy, Progressive Multifocal / Radiopharmaceuticals / Fluorodeoxyglucose F18 / Positron-Emission Tomography / Methionine Limits: Humans / Male / Middle aged Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2017 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flumazenil / Leukoencephalopathy, Progressive Multifocal / Radiopharmaceuticals / Fluorodeoxyglucose F18 / Positron-Emission Tomography / Methionine Limits: Humans / Male / Middle aged Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2017 Document type: Article Affiliation country: Japan