Disseminated Cryptococcosis with Adrenal Insufficiency and Meningitis in an Immunocompetent Individual.
Intern Med
; 56(10): 1259-1264, 2017.
Article
in En
| MEDLINE
| ID: mdl-28502948
ABSTRACT
We present a case of cryptococcosis with adrenal insufficiency and meningitis in a healthy host without any risk factors. Antifungal therapy did not reduce the cryptococcal antigen titers of the cerebrospinal fluid and serum or the bilateral adrenal gland enlargement. It was suggested that the adrenal glands were the focus of persistent fungemia. Removal of both adrenal glands brought about a response to antifungal therapy. We conclude that if antifungal therapy is ineffective, bilateral adrenalectomy is an effective measure for treatment of such patients. Cryptococcosis is a possible cause of primary adrenal insufficiency in immunocompetent patients.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Addison Disease
/
Cryptococcosis
/
Meningitis
/
Antifungal Agents
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Intern Med
Journal subject:
MEDICINA INTERNA
Year:
2017
Document type:
Article
Affiliation country:
Japan