Anti-inflammatory, anti-osteoclastic, and antioxidant activities of genistein protect against alveolar bone loss and periodontal tissue degradation in a mouse model of periodontitis.

Bhattarai, Govinda; Poudel, Sher Bahadur; Kook, Sung-Ho; Lee, Jeong-Chae

Bhattarai, Govinda; Poudel, Sher Bahadur; Kook, Sung-Ho; Lee, Jeong-Chae.

Affiliation

Bhattarai G; Cluster for Craniofacial Development & Regeneration Research, Institute of Oral Biosciences (BK21 program) and School of Dentistry, Chonbuk National University, Jeonju, 54896, South Korea.
Poudel SB; Cluster for Craniofacial Development & Regeneration Research, Institute of Oral Biosciences (BK21 program) and School of Dentistry, Chonbuk National University, Jeonju, 54896, South Korea.
Kook SH; Cluster for Craniofacial Development & Regeneration Research, Institute of Oral Biosciences (BK21 program) and School of Dentistry, Chonbuk National University, Jeonju, 54896, South Korea.
Lee JC; Department of Bioactive Material Sciences, Chonbuk National University, Jeonju, 54896, South Korea.

J Biomed Mater Res A ; 105(9): 2510-2521, 2017 Sep.

Article in En | MEDLINE | ID: mdl-28509410

Subject(s)

Alveolar Bone Loss/drug therapy; Anti-Inflammatory Agents/therapeutic use; Antioxidants/therapeutic use; Genistein/therapeutic use; Osteoclasts/pathology; Periodontitis/drug therapy; Periodontium/pathology; Alveolar Bone Loss/complications; Alveolar Bone Loss/pathology; Animals; Anti-Inflammatory Agents/pharmacology; Antioxidants/pharmacology; Autophagy/drug effects; Cell Death/drug effects; Cell Differentiation/drug effects; Cell Survival/drug effects; Disease Models, Animal; Genistein/pharmacology; Gingiva/pathology; Humans; Inflammation/pathology; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Organelle Biogenesis; Osteoclasts/drug effects; Osteoclasts/metabolism; Periodontitis/complications; Periodontitis/pathology; Periodontium/drug effects; Protective Agents/pharmacology; Protective Agents/therapeutic use; RANK Ligand/pharmacology; RAW 264.7 Cells; Reactive Oxygen Species/metabolism; Stress, Physiological/drug effects

Key words

autophagy; genistein; inflammation-related molecules; osteoclastogenesis; oxidative stress; periodontitis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoclasts / Periodontitis / Periodontium / Alveolar Bone Loss / Genistein / Anti-Inflammatory Agents / Antioxidants Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Biomed Mater Res A Journal subject: ENGENHARIA BIOMEDICA Year: 2017 Document type: Article Affiliation country: South Korea

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