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A new approach for the evaluation of recovery after peripheral nerve damage.
van der Hoop, R G; Brakkee, J H; Kapelle, A; Samson, M; de Koning, P; Gispen, W H.
Affiliation
  • van der Hoop RG; Division of Molecular Neurobiology, Rudolf Magnus Institute for Pharmacology, University of Utrecht, The Netherlands.
J Neurosci Methods ; 26(2): 111-6, 1988 Dec.
Article in En | MEDLINE | ID: mdl-2851075
ABSTRACT
The major caudal nerves of the rat provide an excellent model for longitudinal evaluation of nerve repair following a crush lesion. The surgical procedure and the method for testing sensory recovery are described in detail. Using this technique a clear, positive effect of ORG.2766 (an ACTH (4-9) analog) on the regeneration of sensory nerves could be shown. Results support the suggestion that ORG.2766 enhances the initial sprouting response, rather than exerting an effect on the growth rate of newly developed sprouts.
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Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Adrenocorticotropic Hormone / Peripheral Nerve Injuries / Nerve Regeneration / Neurons, Afferent Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurosci Methods Year: 1988 Document type: Article Affiliation country: Netherlands
Search on Google
Add to My VHL
Print
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Adrenocorticotropic Hormone / Peripheral Nerve Injuries / Nerve Regeneration / Neurons, Afferent Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurosci Methods Year: 1988 Document type: Article Affiliation country: Netherlands