Hippo signalling in intestinal regeneration and cancer.
Curr Opin Cell Biol
; 48: 17-25, 2017 10.
Article
in En
| MEDLINE
| ID: mdl-28527754
ABSTRACT
The Hippo pathway is a unique signalling module that regulates cell-specific transcriptional responses and responds to a wide range of intrinsic and extrinsic cues. Besides its classical role in restricting tissue size during development, Hippo signalling is now recognized to control numerous processes including cell proliferation, survival, cell fate determination, epithelial-to-mesenchymal transitions and cell migration. Because of its highly dynamic nature, the intestinal epithelium has served as an exceptional model to study the complex roles of Hippo signalling. In this review, we shall present an overview of Hippo function in the mammalian intestine and discuss the various mechanisms regulating Hippo signalling and how they contribute to intestinal regeneration and cancer.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Protein Serine-Threonine Kinases
/
Intestinal Mucosa
/
Intestinal Neoplasms
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Cell Biol
Year:
2017
Document type:
Article
Affiliation country:
Canada