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Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells.
Fortin, Sébastien; Charest-Morin, Xavier; Turcotte, Vanessa; Lauvaux, Coraline; Lacroix, Jacques; Côté, Marie-France; Gobeil, Stéphane; C-Gaudreault, René.
Affiliation
  • Fortin S; CHU de Québec Research Centre, Oncology Division, Hôpital Saint-François d'Assise , 10 rue de l'Espinay, Quebec City, Quebec, Canada G1L 3L5.
  • Charest-Morin X; Faculty of Pharmacy, Université Laval , Quebec City, Quebec, Canada G1V 0A6.
  • Turcotte V; CHU de Québec Research Centre, Oncology Division, Hôpital Saint-François d'Assise , 10 rue de l'Espinay, Quebec City, Quebec, Canada G1L 3L5.
  • Lauvaux C; CHU de Québec Research Centre, Oncology Division, Hôpital Saint-François d'Assise , 10 rue de l'Espinay, Quebec City, Quebec, Canada G1L 3L5.
  • Lacroix J; CHU de Québec Research Centre, Endocrinology and Nephrology Division, CHUL , 2705 Boulevard Laurier, Quebec City, Quebec, Canada G1V 4G2.
  • Côté MF; CHU de Québec Research Centre, Oncology Division, Hôpital Saint-François d'Assise , 10 rue de l'Espinay, Quebec City, Quebec, Canada G1L 3L5.
  • Gobeil S; CHU de Québec Research Centre, Oncology Division, Hôpital Saint-François d'Assise , 10 rue de l'Espinay, Quebec City, Quebec, Canada G1L 3L5.
  • C-Gaudreault R; CHU de Québec Research Centre, Endocrinology and Nephrology Division, CHUL , 2705 Boulevard Laurier, Quebec City, Quebec, Canada G1V 4G2.
J Med Chem ; 60(12): 4963-4982, 2017 06 22.
Article in En | MEDLINE | ID: mdl-28535350
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzenesulfonates / Breast Neoplasms / Prodrugs / Cytochrome P-450 CYP1A1 / Antimitotic Agents Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzenesulfonates / Breast Neoplasms / Prodrugs / Cytochrome P-450 CYP1A1 / Antimitotic Agents Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article