Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes.

Giacomelli, E; Mummery, C L; Bellin, M

Giacomelli, E; Mummery, C L; Bellin, M.

Affiliation

Giacomelli E; Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.
Mummery CL; Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.
Bellin M; Department of Applied Stem Cell Technologies, University of Twente, Building Zuidhorst, 7500 AE, Enschede, The Netherlands.

Cell Mol Life Sci ; 74(20): 3711-3739, 2017 10.

Article in En | MEDLINE | ID: mdl-28573431

Subject(s)

Heart Diseases/pathology; Myocytes, Cardiac/pathology; Calcium/metabolism; Cell Differentiation; Heart Diseases/genetics; Heart Diseases/metabolism; Humans; Metabolome; Mitochondria/genetics; Mitochondria/metabolism; Mitochondria/pathology; Mutation; Myocytes, Cardiac/cytology; Myocytes, Cardiac/metabolism; Pluripotent Stem Cells/cytology; Pluripotent Stem Cells/metabolism; Pluripotent Stem Cells/pathology; Sarcomeres/genetics; Sarcomeres/metabolism; Sarcomeres/pathology

Key words

Cardiac arrhythmia; Cardiac disease; Cardiomyopathy; Cardiovascular disease; Disease modeling; Drug screening; Human pluripotent stem cell-derived cardiomyocytes; Safety pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocytes, Cardiac / Heart Diseases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Mol Life Sci Journal subject: BIOLOGIA MOLECULAR Year: 2017 Document type: Article Affiliation country: Netherlands Country of publication: Switzerland

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