Extracorporeal photochemotherapy in mycosis fungoides.
Transfus Clin Biol
; 24(4): 454-457, 2017 Nov.
Article
in En
| MEDLINE
| ID: mdl-28578935
ABSTRACT
OBJECTIVES:
Extracorporeal photo-chemotherapy (ECP, photopheresis) is an approved treatment modality for mycosis fungoides (MF). Our aim is to present our ECP data for MF.METHODS:
We retrospectively evaluated 50 MF patients who received ECP for clinical activity, toxicity, and response and outcome rates, and we compared these with combination therapies.RESULTS:
The overall response rate (ORR) was 42% (21/50), while the median time to response was 11months (range, 3-48months). Ten of the responders (48%) had 3 or more treatment lines prior to ECP. Eight patients (16%) had adverse events related to ECP. The overall survival (OS) of 50 patients was 72months (range, 3-211). There was no statistically significant difference in the OS in early-stage vs late-stage patients (77 vs 69months, P=0.077). The stage 3 and 4 patients received an average of 31 cycles compared to 55 cycles in stage 1 and 2 patients (P=0.006). The increased extent of ECP was not correlated with the response. Combined treatment with ECP significantly improved the OS (84months vs 62months, P=0.005).DISCUSSION:
A low frequency of side effects and improved OS observed in combination therapy makes ECP a favorable option for treating MF.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mycosis Fungoides
/
Photopheresis
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Transfus Clin Biol
Journal subject:
HEMATOLOGIA
Year:
2017
Document type:
Article