Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability.

Luz, Anthony L; Godebo, Tewodros R; Smith, Latasha L; Leuthner, Tess C; Maurer, Laura L; Meyer, Joel N

Luz, Anthony L; Godebo, Tewodros R; Smith, Latasha L; Leuthner, Tess C; Maurer, Laura L; Meyer, Joel N.

Affiliation

Luz AL; Nicholas School of the Environment, Box 90328, Duke University, Durham, NC, 27708, USA.
Godebo TR; Nicholas School of the Environment, Box 90328, Duke University, Durham, NC, 27708, USA.
Smith LL; Nicholas School of the Environment, Box 90328, Duke University, Durham, NC, 27708, USA.
Leuthner TC; Nicholas School of the Environment, Box 90328, Duke University, Durham, NC, 27708, USA.
Maurer LL; ExxonMobil Biomedical Sciences, Inc., Annandale, NJ, 08801-3059, USA.
Meyer JN; Nicholas School of the Environment, Box 90328, Duke University, Durham, NC, 27708, USA. Electronic address: joel.meyer@duke.edu.

Toxicology ; 387: 81-94, 2017 07 15.

Article in En | MEDLINE | ID: mdl-28602540

Subject(s)

Arsenites/toxicity; Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/drug effects; Mitochondria/drug effects; Mitochondrial Dynamics/drug effects; Sodium Compounds/toxicity; Animals; Autophagy/drug effects; Caenorhabditis elegans/embryology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins/genetics; Dose-Response Relationship, Drug; Dynamins/genetics; Dynamins/metabolism; GTP Phosphohydrolases/genetics; GTP Phosphohydrolases/metabolism; Gene-Environment Interaction; Genotype; Larva/drug effects; Larva/metabolism; Mitochondria/metabolism; Mitophagy/drug effects; Phenotype; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Ubiquitin-Protein Ligases/genetics; Ubiquitin-Protein Ligases/metabolism

Key words

Arsenite; Gene-environment interaction; Mitochondrial fission; Mitochondrial fusion; Mitochondrial toxicity; Mitophagy

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Caenorhabditis elegans / Sodium Compounds / Arsenites / Caenorhabditis elegans Proteins / Mitochondrial Dynamics / Mitochondria Type of study: Prognostic_studies Limits: Animals Language: En Journal: Toxicology Year: 2017 Document type: Article Affiliation country: United States Country of publication: Ireland

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google