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Tanshinone IIA inhibits ß-catenin/VEGF-mediated angiogenesis by targeting TGF-ß1 in normoxic and HIF-1α in hypoxic microenvironments in human colorectal cancer.
Sui, Hua; Zhao, Jihui; Zhou, Lihong; Wen, Haotian; Deng, Wanli; Li, Chunpu; Ji, Qing; Liu, Xuan; Feng, Yuanyuan; Chai, Ni; Zhang, Qibo; Cai, Jianfeng; Li, Qi.
Affiliation
  • Sui H; Department of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Zhao J; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Zhou L; Department of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Wen H; Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Deng W; Department of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Li C; Department of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Ji Q; Department of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Liu X; Department of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Feng Y; Department of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Chai N; Department of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Zhang Q; Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Cai J; Department of Chemistry, University of South Florida, Tampa, FL 33612, USA.
  • Li Q; Department of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: Lzwf@hotmail.com.
Cancer Lett ; 403: 86-97, 2017 09 10.
Article in En | MEDLINE | ID: mdl-28602978
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Angiogenesis Inhibitors / Abietanes / Vascular Endothelial Growth Factor A / Beta Catenin / Hypoxia-Inducible Factor 1, alpha Subunit / Transforming Growth Factor beta1 / Tumor Microenvironment / Tumor Hypoxia / Neovascularization, Pathologic Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male / Middle aged Language: En Journal: Cancer Lett Year: 2017 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Angiogenesis Inhibitors / Abietanes / Vascular Endothelial Growth Factor A / Beta Catenin / Hypoxia-Inducible Factor 1, alpha Subunit / Transforming Growth Factor beta1 / Tumor Microenvironment / Tumor Hypoxia / Neovascularization, Pathologic Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male / Middle aged Language: En Journal: Cancer Lett Year: 2017 Document type: Article Affiliation country: China