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Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ.
Fujita, Junso; Maeda, Yoko; Mizohata, Eiichi; Inoue, Tsuyoshi; Kaul, Malvika; Parhi, Ajit K; LaVoie, Edmond J; Pilch, Daniel S; Matsumura, Hiroyoshi.
Affiliation
  • Fujita J; Department of Applied Chemistry, Graduate School of Engineering, Osaka University , 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
  • Maeda Y; Department of Applied Chemistry, Graduate School of Engineering, Osaka University , 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
  • Mizohata E; Department of Applied Chemistry, Graduate School of Engineering, Osaka University , 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
  • Inoue T; Department of Applied Chemistry, Graduate School of Engineering, Osaka University , 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
  • Kaul M; Department of Pharmacology, Rutgers Robert Wood Johnson Medical School , 675 Hoes Lane, Piscataway, New Jersey 08854, United States.
  • Parhi AK; TAXIS Pharmaceuticals, Inc. , 9 Deer Park Drive, Suite J-15, Monmouth Junction, New Jersey 08852, United States.
  • LaVoie EJ; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University , 160 Frelinghuysen Road, Piscataway, New Jersey 08854, United States.
  • Pilch DS; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University , 160 Frelinghuysen Road, Piscataway, New Jersey 08854, United States.
  • Matsumura H; Department of Pharmacology, Rutgers Robert Wood Johnson Medical School , 675 Hoes Lane, Piscataway, New Jersey 08854, United States.
ACS Chem Biol ; 12(7): 1947-1955, 2017 07 21.
Article in En | MEDLINE | ID: mdl-28621933
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Drug Resistance / Cytoskeletal Proteins / Methicillin-Resistant Staphylococcus aureus / Mutation Type of study: Prognostic_studies Language: En Journal: ACS Chem Biol Year: 2017 Document type: Article Affiliation country: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Drug Resistance / Cytoskeletal Proteins / Methicillin-Resistant Staphylococcus aureus / Mutation Type of study: Prognostic_studies Language: En Journal: ACS Chem Biol Year: 2017 Document type: Article Affiliation country: Japan