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Epigallocatechin-3-gallate and related phenol compounds redirect the amyloidogenic aggregation pathway of ataxin-3 towards non-toxic aggregates and prevent toxicity in neural cells and Caenorhabditis elegans animal model.
Visentin, Cristina; Pellistri, Francesca; Natalello, Antonino; Vertemara, Jacopo; Bonanomi, Marcella; Gatta, Elena; Penco, Amanda; Relini, Annalisa; De Gioia, Luca; Airoldi, Cristina; Regonesi, Maria E; Tortora, Paolo.
Affiliation
  • Visentin C; Department of Biotechnologies and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.
  • Pellistri F; Department of Physics, University of Genoa, 16146 Genoa, Italy.
  • Natalello A; Department of Biotechnologies and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.
  • Vertemara J; Milan Center of Neuroscience (NeuroMI), 20126 Milan, Italy.
  • Bonanomi M; Department of Biotechnologies and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.
  • Gatta E; Department of Biotechnologies and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.
  • Penco A; Department of Physics, University of Genoa, 16146 Genoa, Italy.
  • Relini A; Department of Physics, University of Genoa, 16146 Genoa, Italy.
  • De Gioia L; Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.
  • Airoldi C; Department of Physics, University of Genoa, 16146 Genoa, Italy.
  • Regonesi ME; National Institute of Biostructures and Biosystems (INBB), 00136 Rome, Italy.
  • Tortora P; Department of Biotechnologies and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.
Hum Mol Genet ; 26(17): 3271-3284, 2017 09 01.
Article in En | MEDLINE | ID: mdl-28633380
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Catechin / Ataxin-3 Limits: Animals / Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2017 Document type: Article Affiliation country: Italy Country of publication: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Catechin / Ataxin-3 Limits: Animals / Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2017 Document type: Article Affiliation country: Italy Country of publication: United kingdom