Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells.
Cell Rep
; 19(12): 2469-2476, 2017 06 20.
Article
in En
| MEDLINE
| ID: mdl-28636936
ABSTRACT
Despite a growing appreciation of γδ T cell contributions to numerous immune responses, the mechanisms that underpin their thymic development remain poorly understood. Here, using precursor/product relationships, we identify thymic stages in two distinct developmental pathways that generate γδ T cells pre-committed to subsequent secretion of either IL-17A or IFNγ. Importantly, this framework for tracking γδ T cell development has permitted definitive assessment of TCRγδ signal strength in commitment to γδ T cell effector fate; increased TCRγδ signal strength profoundly prohibited the development of all IL-17A-secreting γδ T cells, regardless of Vγ usage, but promoted the development of γδ progenitors along the IFNγ pathway. This clarifies the recently debated role of TCRγδ signal strength in commitment to distinct γδ T cell effector fates and proposes an alternate methodology for the study of γδ T cell development.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
T-Lymphocytes
/
Receptors, Antigen, T-Cell, gamma-delta
/
Interleukin-17
Limits:
Animals
Language:
En
Journal:
Cell Rep
Year:
2017
Document type:
Article
Affiliation country:
United kingdom