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The CLOSED trial; CLOnidine compared with midazolam for SEDation of paediatric patients in the intensive care unit: study protocol for a multicentre randomised controlled trial.
Neubert, Antje; Baarslag, Manuel Alberto; Dijk, Monique van; Rosmalen, Joost van; Standing, Joseph F; Sheng, Yucheng; Rascher, Wolfgang; Roberts, Deborah; Winslade, Jackie; Rawcliffe, Louise; Hanning, Sara M; Metsvaht, Tuuli; Giannuzzi, Viviana; Larsson, Peter; Pokorná, Pavla; Simonetti, Alessandra; Tibboel, Dick.
Affiliation
  • Neubert A; Department of Children and Adolescents Medicine, Friedrich-Alexander-University Erlangen/Nuremberg, Erlangen, Germany.
  • Baarslag MA; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children’s Hospital, Rotterdam, The Netherlands.
  • Dijk MV; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children’s Hospital, Rotterdam, The Netherlands.
  • Rosmalen JV; Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands.
  • Standing JF; Institute of Child Health, University College London, London, United Kingdom.
  • Sheng Y; Institute of Child Health, University College London, London, United Kingdom.
  • Rascher W; Department of Children and Adolescents Medicine, Friedrich-Alexander-University Erlangen/Nuremberg, Erlangen, Germany.
  • Roberts D; Therakind Ltd, London, United Kingdom.
  • Winslade J; Therakind Ltd, London, United Kingdom.
  • Rawcliffe L; Therakind Ltd, London, United Kingdom.
  • Hanning SM; UCL School of Pharmacy, University College London, London, United Kingdom.
  • Metsvaht T; Clinic of Anaesthesiology and Intensive Care, Tartu University Hospital, Tartu, Estonia.
  • Giannuzzi V; Fondazione per la Ricerca Farmacologica Gianni Benzi onlus, Valenzano, Italy.
  • Larsson P; Department of Pediatric Anesthesia and Intensive Care, Astrid Lindgrens Childrens Hospital, Karolinska University Hospital, Stockholm, Sweden.
  • Pokorná P; Department of Pediatrics, First Faculty of Medicine, Charles University Prague, Prague, Czech Republic.
  • Simonetti A; Clinical Trial Center, Bambino Gesù Children's Hospital, Rome, Italy.
  • Tibboel D; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children’s Hospital, Rotterdam, The Netherlands.
BMJ Open ; 7(6): e016031, 2017 06 21.
Article in En | MEDLINE | ID: mdl-28637741

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Research Design / Midazolam / Clonidine / Hypnotics and Sedatives Type of study: Clinical_trials Aspects: Ethics Limits: Adolescent / Child / Child, preschool / Humans / Infant / Newborn Language: En Journal: BMJ Open Year: 2017 Document type: Article Affiliation country: Germany Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Research Design / Midazolam / Clonidine / Hypnotics and Sedatives Type of study: Clinical_trials Aspects: Ethics Limits: Adolescent / Child / Child, preschool / Humans / Infant / Newborn Language: En Journal: BMJ Open Year: 2017 Document type: Article Affiliation country: Germany Country of publication: United kingdom