Modulation of the heart's electrical properties by the anticonvulsant drug retigabine.

Rubi, Lena; Kovar, Michael; Zebedin-Brandl, Eva; Koenig, Xaver; Dominguez-Rodriguez, Manuel; Todt, Hannes; Kubista, Helmut; Boehm, Stefan; Hilber, Karlheinz

Rubi, Lena; Kovar, Michael; Zebedin-Brandl, Eva; Koenig, Xaver; Dominguez-Rodriguez, Manuel; Todt, Hannes; Kubista, Helmut; Boehm, Stefan; Hilber, Karlheinz.

Affiliation

Rubi L; Center for Physiology and Pharmacology, Department of Neurophysiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Kovar M; Center for Physiology and Pharmacology, Department of Neurophysiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Zebedin-Brandl E; Center for Physiology and Pharmacology, Department of Neurophysiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Koenig X; Center for Physiology and Pharmacology, Department of Neurophysiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Dominguez-Rodriguez M; Center for Physiology and Pharmacology, Department of Neurophysiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Todt H; Center for Physiology and Pharmacology, Department of Neurophysiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Kubista H; Center for Physiology and Pharmacology, Department of Neurophysiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Boehm S; Center for Physiology and Pharmacology, Department of Neurophysiology and Pharmacology, Medical University of Vienna, Vienna, Austria. Electronic address: stefan.boehm@meduniwien.ac.at.
Hilber K; Center for Physiology and Pharmacology, Department of Neurophysiology and Pharmacology, Medical University of Vienna, Vienna, Austria. Electronic address: karlheinz.hilber@meduniwien.ac.at.

Toxicol Appl Pharmacol ; 329: 309-317, 2017 08 15.

Article in En | MEDLINE | ID: mdl-28641963

Subject(s)

Action Potentials/drug effects; Anticonvulsants/toxicity; Arrhythmias, Cardiac/chemically induced; Carbamates/toxicity; Ganglia, Sympathetic/drug effects; Ganglionic Blockers/toxicity; Heart Conduction System/drug effects; Ion Channels/antagonists & inhibitors; Myocytes, Cardiac/drug effects; Phenylenediamines/toxicity; Animals; Arrhythmias, Cardiac/metabolism; Arrhythmias, Cardiac/physiopathology; Calcium Channel Blockers/toxicity; Calcium Channels, L-Type/drug effects; Calcium Channels, L-Type/metabolism; Cell Line; Dose-Response Relationship, Drug; ERG1 Potassium Channel/antagonists & inhibitors; ERG1 Potassium Channel/metabolism; Ganglia, Sympathetic/metabolism; Ganglia, Sympathetic/physiopathology; Guinea Pigs; Heart Conduction System/metabolism; Heart Conduction System/physiopathology; Heart Rate/drug effects; Humans; Induced Pluripotent Stem Cells/drug effects; Induced Pluripotent Stem Cells/metabolism; Ion Channels/genetics; Ion Channels/metabolism; Isolated Heart Preparation; Myocytes, Cardiac/metabolism; NAV1.5 Voltage-Gated Sodium Channel/drug effects; NAV1.5 Voltage-Gated Sodium Channel/metabolism; Norepinephrine/metabolism; Potassium Channel Blockers/toxicity; Rats, Sprague-Dawley; Risk Assessment; Time Factors; Transfection; Voltage-Gated Sodium Channel Blockers/toxicity

Key words

Cardiac arrhythmia; Cardiomyocytes; Ion channels; QT interval; Retigabine; Sympathetic ganglionic neurons

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylenediamines / Arrhythmias, Cardiac / Action Potentials / Carbamates / Myocytes, Cardiac / Ganglia, Sympathetic / Ganglionic Blockers / Heart Conduction System / Ion Channels / Anticonvulsants Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Toxicol Appl Pharmacol Year: 2017 Document type: Article Affiliation country: Austria Country of publication: United States

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