Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors.

Yates, Christopher M; Garvey, Edward P; Shaver, Sammy R; Schotzinger, Robert J; Hoekstra, William J

Yates, Christopher M; Garvey, Edward P; Shaver, Sammy R; Schotzinger, Robert J; Hoekstra, William J.

Affiliation

Yates CM; Viamet Pharmaceuticals Inc., Durham, NC 27703, USA. Electronic address: cyates@viamet.com.
Garvey EP; Viamet Pharmaceuticals Inc., Durham, NC 27703, USA.
Shaver SR; Viamet Pharmaceuticals Inc., Durham, NC 27703, USA.
Schotzinger RJ; Viamet Pharmaceuticals Inc., Durham, NC 27703, USA.
Hoekstra WJ; Viamet Pharmaceuticals Inc., Durham, NC 27703, USA.

Bioorg Med Chem Lett ; 27(15): 3243-3248, 2017 08 01.

Article in En | MEDLINE | ID: mdl-28651982

Subject(s)

14-alpha Demethylase Inhibitors/chemistry; 14-alpha Demethylase Inhibitors/pharmacology; Antifungal Agents/chemistry; Antifungal Agents/pharmacology; Azoles/chemistry; Azoles/pharmacology; Fungi/enzymology; Aspergillosis/drug therapy; Aspergillosis/microbiology; Aspergillus fumigatus/drug effects; Aspergillus fumigatus/enzymology; Cytochrome P450 Family 51/antagonists & inhibitors; Cytochrome P450 Family 51/metabolism; Drug Design; Fungi/drug effects; Humans; Molecular Docking Simulation; Mycoses/drug therapy; Mycoses/microbiology; Pyridines/chemistry; Pyridines/pharmacology; Tetrazoles/chemistry; Tetrazoles/pharmacology

Key words

Antifungal; Azole; CYP51; Fungal infection; Lanosterol 14 α-demethylase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azoles / 14-alpha Demethylase Inhibitors / Fungi / Antifungal Agents Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2017 Document type: Article Country of publication: United kingdom

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