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BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity.
Emery, Caroline M; Monaco, Kelli-Ann; Wang, Ping; Balak, Marissa; Freeman, Alyson; Meltzer, Jodi; Delach, Scott M; Rakiec, Daniel; Ruddy, David A; Korn, Joshua M; Haling, Jacob; Acker, Michael G; Caponigro, Giordano.
Affiliation
  • Emery CM; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Monaco KA; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Wang P; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Balak M; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Freeman A; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Meltzer J; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Delach SM; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Rakiec D; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Ruddy DA; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Korn JM; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Haling J; Oncology Pharmacology, Genomics Institute of the Novartis Research Foundation, San Diego, California.
  • Acker MG; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
  • Caponigro G; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts. giordano.caponigro@novartis.com.
Mol Cancer Res ; 15(10): 1431-1444, 2017 10.
Article in En | MEDLINE | ID: mdl-28655712
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Raf Kinases / MAP Kinase Kinase 1 / MAP Kinase Kinase 2 / Protein Kinase Inhibitors / Mutation Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Mol Cancer Res Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2017 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Raf Kinases / MAP Kinase Kinase 1 / MAP Kinase Kinase 2 / Protein Kinase Inhibitors / Mutation Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Mol Cancer Res Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2017 Document type: Article Country of publication: United States