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Detection of long term cellular immune response to Japanese encephalitis vaccination using IFN-γ ELIspot assay.
Zia, Amreen; Singh, Dharamveer; Saxena, Swati; Umrao, Jyoti; Baluni, Manjari; Ghildiyal, Sneha; Fatima, Tanzeem; Shukla, Mukti; Agarwal, Vikas; Dhole, Tapan N.
Affiliation
  • Zia A; Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  • Singh D; Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  • Saxena S; Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  • Umrao J; Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  • Baluni M; Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  • Ghildiyal S; Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  • Fatima T; Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  • Shukla M; Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  • Agarwal V; Department of Clinical Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  • Dhole TN; Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
J Med Virol ; 89(12): 2235-2238, 2017 12.
Article in En | MEDLINE | ID: mdl-28671301
ABSTRACT
Vaccine is the most effective preventive measure against Japanese Encephalitis infection. Role of IFN-γ expressing T cells for JE virus clearance has been described as a part of cellular immunity. Vaccine induced immunity also involve the cellular immune response, therefore the study was aimed to observe induction and persistence of IFN-γ expressing T cells by IFN-γ ELISpot assay. The cell count increased significantly after 28 (P < 0.0001) days post vaccination, and remained higher at all time points (day 28, day 180, day 360) when compared with prevaccination. This study will be helpful for designing future vaccination strategy and improving vaccine efficacy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon-gamma / Encephalitis, Japanese / Japanese Encephalitis Vaccines / Encephalitis Virus, Japanese / Immunity, Cellular Type of study: Diagnostic_studies Limits: Child, preschool / Female / Humans / Infant / Male Language: En Journal: J Med Virol Year: 2017 Document type: Article Affiliation country: India
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon-gamma / Encephalitis, Japanese / Japanese Encephalitis Vaccines / Encephalitis Virus, Japanese / Immunity, Cellular Type of study: Diagnostic_studies Limits: Child, preschool / Female / Humans / Infant / Male Language: En Journal: J Med Virol Year: 2017 Document type: Article Affiliation country: India