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Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.
Sivanand, Sharanya; Rhoades, Seth; Jiang, Qinqin; Lee, Joyce V; Benci, Joseph; Zhang, Jingwen; Yuan, Salina; Viney, Isabella; Zhao, Steven; Carrer, Alessandro; Bennett, Michael J; Minn, Andy J; Weljie, Aalim M; Greenberg, Roger A; Wellen, Kathryn E.
Affiliation
  • Sivanand S; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Rhoades S; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Jiang Q; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Lee JV; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Benci J; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medici
  • Zhang J; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Yuan S; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Viney I; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Zhao S; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Carrer A; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Bennett MJ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Minn AJ; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medici
  • Weljie AM; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Greenberg RA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Wellen KE; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: wellenk@upenn.edu.
Mol Cell ; 67(2): 252-265.e6, 2017 Jul 20.
Article in En | MEDLINE | ID: mdl-28689661
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetyl Coenzyme A / ATP Citrate (pro-S)-Lyase / Cell Nucleus / BRCA1 Protein / DNA Breaks, Double-Stranded / Recombinational DNA Repair Limits: Animals / Female / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetyl Coenzyme A / ATP Citrate (pro-S)-Lyase / Cell Nucleus / BRCA1 Protein / DNA Breaks, Double-Stranded / Recombinational DNA Repair Limits: Animals / Female / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States