Identity of Gli1+ cells in the bone marrow.
Exp Hematol
; 54: 12-16, 2017 10.
Article
in En
| MEDLINE
| ID: mdl-28690072
ABSTRACT
Bone marrow fibrosis is a critical component of primary myelofibrosis in which normal bone marrow tissue and blood-forming cells are gradually replaced with scar tissue. The specific cellular and molecular mechanisms that cause bone marrow fibrosis are not understood. A recent study using state-of-the-art techniques, including in vivo lineage tracing, provides evidence that Gli1+ cells are the cells responsible for fibrotic disease in the bone marrow. Strikingly, genetic depletion of Gli1+ cells rescues bone marrow failure and abolishes myelofibrosis. This work introduces a new central cellular target for bone marrow fibrosis. The knowledge that emerges from this research will be important for the treatment of several malignant and nonmalignant disorders.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyridines
/
Pyrimidines
/
Platelet Factor 4
/
Bone Marrow Cells
/
Primary Myelofibrosis
/
Molecular Targeted Therapy
/
Zinc Finger Protein GLI1
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Exp Hematol
Year:
2017
Document type:
Article
Affiliation country:
Brazil