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Identity of Gli1+ cells in the bone marrow.
Sena, Isadora F G; Prazeres, Pedro H D M; Santos, Gabryella S P; Borges, Isabella T; Azevedo, Patrick O; Andreotti, Julia P; Almeida, Viviani M; Paiva, Ana E; Guerra, Daniel A P; Lousado, Luiza; Souto, Luanny; Mintz, Akiva; Birbrair, Alexander.
Affiliation
  • Sena IFG; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Prazeres PHDM; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Santos GSP; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Borges IT; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Azevedo PO; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Andreotti JP; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Almeida VM; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Paiva AE; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Guerra DAP; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Lousado L; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Souto L; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Mintz A; Department of Radiology, Wake Forest School of Medicine, Winston Salem, NC, USA.
  • Birbrair A; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Br
Exp Hematol ; 54: 12-16, 2017 10.
Article in En | MEDLINE | ID: mdl-28690072
ABSTRACT
Bone marrow fibrosis is a critical component of primary myelofibrosis in which normal bone marrow tissue and blood-forming cells are gradually replaced with scar tissue. The specific cellular and molecular mechanisms that cause bone marrow fibrosis are not understood. A recent study using state-of-the-art techniques, including in vivo lineage tracing, provides evidence that Gli1+ cells are the cells responsible for fibrotic disease in the bone marrow. Strikingly, genetic depletion of Gli1+ cells rescues bone marrow failure and abolishes myelofibrosis. This work introduces a new central cellular target for bone marrow fibrosis. The knowledge that emerges from this research will be important for the treatment of several malignant and nonmalignant disorders.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Pyrimidines / Platelet Factor 4 / Bone Marrow Cells / Primary Myelofibrosis / Molecular Targeted Therapy / Zinc Finger Protein GLI1 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Exp Hematol Year: 2017 Document type: Article Affiliation country: Brazil
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Pyrimidines / Platelet Factor 4 / Bone Marrow Cells / Primary Myelofibrosis / Molecular Targeted Therapy / Zinc Finger Protein GLI1 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Exp Hematol Year: 2017 Document type: Article Affiliation country: Brazil