The validation of an LC-MS/MS assay for perhexiline and major hydroxy metabolites, and its application to therapeutic monitoring in patient plasma.

Camilleri, Patrick; Zhang, Duxi; Midei, Mark; Daly, William; Copp, James; Flinn, Cindy; Luongo, Carl; Shamszad, Pirouz

Camilleri, Patrick; Zhang, Duxi; Midei, Mark; Daly, William; Copp, James; Flinn, Cindy; Luongo, Carl; Shamszad, Pirouz.

Affiliation

Camilleri P; Bio-Chemical Solutions, 5 Morgan Close, Stevenage, Hertfordshire SG1 4TG, UK.
Zhang D; Medpace, Inc., 5375 Medpace Way, Cincinnati, OH 45227 USA.
Midei M; Heart Metabolics USA Inc., 1700 Owens Street, Suite 595, San Francisco, CA 94158, USA.
Daly W; Heart Metabolics USA Inc., 1700 Owens Street, Suite 595, San Francisco, CA 94158, USA.
Copp J; PO Box 901, Silverthorne, CO 80498, USA.
Flinn C; Heart Metabolics USA Inc., 1700 Owens Street, Suite 595, San Francisco, CA 94158, USA.
Luongo C; Medpace, Inc., 5375 Medpace Way, Cincinnati, OH 45227 USA.
Shamszad P; Medpace, Inc., 5375 Medpace Way, Cincinnati, OH 45227 USA.

Bioanalysis ; 9(13): 1011-1025, 2017 Jul.

Article in En | MEDLINE | ID: mdl-28692346

Subject(s)

Blood Chemical Analysis/methods; Chromatography, High Pressure Liquid/methods; Drug Monitoring/methods; Perhexiline/blood; Perhexiline/metabolism; Tandem Mass Spectrometry/methods; Calibration; Humans; Quality Control

Key words

LCMS/MS; assay validation; novel internal standards; perhexiline. hydroxy metabolites; therapeutic monitoring

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Chemical Analysis / Perhexiline / Chromatography, High Pressure Liquid / Drug Monitoring / Tandem Mass Spectrometry Type of study: Guideline Limits: Humans Language: En Journal: Bioanalysis Year: 2017 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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