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Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents.
Sahu, Pramod K; Umme, Tamima; Yu, Jinha; Kim, Gyudong; Qu, Shuhao; Naik, Siddhi D; Jeong, Lak Shin.
Affiliation
  • Sahu PK; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea. pramodksahu@gmail.com.
  • Umme T; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea. jhini19@gmail.com.
  • Yu J; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea. jinha.yu@nih.gov.
  • Kim G; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea. gdkim0217@gmail.com.
  • Qu S; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea. shuhaoqus@gmail.com.
  • Naik SD; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea. siddhinaik40@gmail.com.
  • Jeong LS; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea. lakjeong@snu.ac.kr.
Molecules ; 22(7)2017 Jul 12.
Article in En | MEDLINE | ID: mdl-28704950
A series of acyclic selenopurine nucleosides 3a-f and 4a-g were synthesized based on the bioisosteric rationale between oxygen and selenium, and then evaluated for antiviral activity. Among the compounds tested, seleno-acyclovir (4a) exhibited the most potent anti-herpes simplex virus (HSV)-1 (EC50 = 1.47 µM) and HSV-2 (EC50 = 6.34 µM) activities without cytotoxicity up to 100 µM, while 2,6-diaminopurine derivatives 4e-g exhibited significant anti-human cytomegalovirus (HCMV) activity, which is slightly more potent than the guanine derivative 4d, indicating that they might act as prodrugs of seleno-ganciclovir (4d).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Purines / Organoselenium Compounds / Nucleosides Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2017 Document type: Article Country of publication: Switzerland
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Purines / Organoselenium Compounds / Nucleosides Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2017 Document type: Article Country of publication: Switzerland