Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine.
J Microbiol Immunol Infect
; 51(5): 598-607, 2018 Oct.
Article
in En
| MEDLINE
| ID: mdl-28709839
ABSTRACT
BACKGROUND:
Asthma is one of the most common allergic diseases. Our previous studies have reported that FIP-fve in acute allergic mouse model can reduce inflammation, improve the balance of the Th1/Th2 system. However, the effects of reducing airway remodeling on FIP-fve is still unknown.OBJECTIVE:
We hypothesized that orally administrated FIP-fve should be able to reduce airway remodeling in chronic allergic models.METHODS:
The chronic asthma animal model was established with 6-8 weeks female Balb/c mice. After intranasal challenges with OVA, the airway inflammation and AHR were determined by a BUXCO system. BALF was analyzed with Liu's stain and ELISA assay. Lung histopathologic changes and Collagen deposition were assayed with H&E, Masson's trichrome and IHC stain.RESULTS:
FIP-fve significantly decreased the number of infiltrating inflammatory cells and Th2 cytokines and increased Th1 cytokines in BALF and serum compared with the OVA sensitized mice. FIP-fve had a better effect than corticosteroid could reduce infiltrating cells in lung especially neutrophils and eosinophils. We also found that the oral FIP-fve group suppressed IL-17 and enhanced IL-22 in the serum and BALF. In addition, oral FIP-fve decreased MMP9 expression, collagen expression and airway remodeling in lung tissues.CONCLUSION:
FIP-fve had anti-inflammatory effects on OVA-induced airway inflammation and an effect to inhibited Th17 cells to reduced airway remodeling and collagen expression. Moreover, FIP-fve might be a potential alternative therapy for allergic airway diseases.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Fungal Proteins
/
Interleukin-17
/
Airway Remodeling
/
Immunomodulation
Limits:
Animals
Language:
En
Journal:
J Microbiol Immunol Infect
Journal subject:
ALERGIA E IMUNOLOGIA
/
MICROBIOLOGIA
Year:
2018
Document type:
Article