Sn- and Ge- triorganometallics exert different cytotoxicity and modulation of migration in triple-negative breast cancer cell line MDA-MB-231.

Hunakova, Luba; Brtko, Julius

Hunakova, Luba; Brtko, Julius.

Affiliation

Hunakova L; Cancer Research Institute, BMC, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovak Republic. Electronic address: exonhun@savba.sk.
Brtko J; Institute of Experimental Endocrinology, BMC, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovak Republic.

Toxicol Lett ; 279: 16-21, 2017 Sep 05.

Article in En | MEDLINE | ID: mdl-28709983

Subject(s)

Antineoplastic Agents/pharmacology; Cell Movement/drug effects; Organometallic Compounds/pharmacology; Organotin Compounds/pharmacology; Triple Negative Breast Neoplasms/drug therapy; Apoptosis/drug effects; Caspase 3/metabolism; Caspase 7/metabolism; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Dose-Response Relationship, Drug; Female; Humans; Inhibitory Concentration 50; Neoplasm Invasiveness; Retinoid X Receptors/drug effects; Retinoid X Receptors/metabolism; Signal Transduction/drug effects; Time Factors; Trialkyltin Compounds/pharmacology; Triple Negative Breast Neoplasms/metabolism; Triple Negative Breast Neoplasms/pathology

Key words

Apoptosis; Cytotoxicity; Nuclear retinoid x receptor; Triorganotin/triorganogermanium derivatives; Triple negative breast cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organometallic Compounds / Organotin Compounds / Cell Movement / Triple Negative Breast Neoplasms / Antineoplastic Agents Limits: Female / Humans Language: En Journal: Toxicol Lett Year: 2017 Document type: Article Country of publication: Netherlands

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