A rare case of atypical chronic lymphocytic leukaemia presenting as nephrotic syndrome.
BMJ Case Rep
; 20172017 Jul 14.
Article
in En
| MEDLINE
| ID: mdl-28710302
ABSTRACT
Chronic lymphocytic leukaemia (CLL) is characterised by a lymphocytosis of mature-appearing clonal CD5+, CD23+ B lymphocytes. CLL cells arise from the bone marrow and infiltrate lymphoid tissues such as lymph nodes and spleen. Presentation is usually through discovery of lymphocytosis or lymphadenopathy. Unusual presentations, especially paraneoplastic syndromes are rare. Here, we describe a rare case presenting with severe nephrotic syndrome associated with the presence of a monoclonal protein in serum. Workup for suspected plasma cell dyscrasia led instead to the diagnosis of bone marrow infiltration by atypical CLL without lymphocytosis. Renal biopsy showed a glomerulonephritis that turned out to be paraneoplastic as it went into remission after treatment for CLL. Our case shows an unusual presentation of CLL and prompts for increased awareness of lymphoproliferative disorders in the context of seemingly unrelated conditions that may be paraneoplastic in origin.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paraneoplastic Syndromes
/
Leukemia, Lymphocytic, Chronic, B-Cell
/
Nephrotic Syndrome
Type of study:
Diagnostic_studies
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
BMJ Case Rep
Year:
2017
Document type:
Article
Affiliation country:
Italy