Loss of the tumour suppressor gene AIP mediates the browning of human brown fat tumours.
J Pathol
; 243(2): 160-164, 2017 10.
Article
in En
| MEDLINE
| ID: mdl-28722204
ABSTRACT
Human brown fat tumours (hibernomas) show concomitant loss of the tumour suppressor genes MEN1 and AIP. We hypothesized that the brown fat phenotype is attributable to these mutations. Accordingly, in this study, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumours, loss of MEN1 was found both in white (one of 51 lipomas) and in brown fat tumours. In contrast, concurrent loss of AIP was always accompanied by a brown fat morphology. We conclude that this white-to-brown phenotype switch in brown fat tumours is mediated by the loss of AIP. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adipose Tissue, Brown
/
Genes, Tumor Suppressor
/
Neoplasms, Adipose Tissue
/
Intracellular Signaling Peptides and Proteins
/
Lipoma
Limits:
Humans
Language:
En
Journal:
J Pathol
Year:
2017
Document type:
Article
Affiliation country:
Sweden