Quantitative physiological measurements to evaluate the response of antivascular endothelial growth factor treatment in patients with neovascular diseases.
Indian J Ophthalmol
; 65(7): 559-568, 2017 Jul.
Article
in En
| MEDLINE
| ID: mdl-28724811
ABSTRACT
Antivascular endothelial growth factor (VEGF) treatment is still used intravitreally worldwide for various neovascular diseases, despite other available, approved treatments. We performed a systematic search of the literature focused on visual physiology studies. We used the online biomedical search engine PubMed and searched key words including "M-chart," "Preferential Hyperacuity Perimetry," "microperimetry," (MP) "electroretinography," and "contrast sensitivity" to estimate treatment efficacy of anti-VEGF treatments in a quantitative manner. Many studies were identified which used a variety of methodologies, disease entities, injected agents, and patient populations, making it difficult to obtain a direct comparison of their results. However, favorable functional outcomes achieved using current quantitative methods would lend further confidence to the effectiveness of a treat-and-extend protocol using intravitreal anti-VEGF for the management of patients with neovascular diseases. Despite anti-VEGF's wide use, a well-designed longitudinal multicenter study to systematically evaluate and compare different physiological methods or parameters in patients with neovascular diseases is still lacking, though it would benefit therapeutic decisions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Contrast Sensitivity
/
Visual Fields
/
Retinal Neovascularization
/
Choroidal Neovascularization
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Angiogenesis Inhibitors
/
Vascular Endothelial Growth Factor A
Type of study:
Clinical_trials
/
Guideline
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Indian J Ophthalmol
Year:
2017
Document type:
Article
Affiliation country:
South Korea