Prospective comparison of 18F-NaF PET/CT versus 18F-FDG PET/CT imaging in mandibular extension of head and neck squamous cell carcinoma with dedicated analysis software and validation with surgical specimen. A preliminary study.
J Craniomaxillofac Surg
; 45(9): 1486-1492, 2017 Sep.
Article
in En
| MEDLINE
| ID: mdl-28764952
ABSTRACT
BACKGROUND:
The aim of this study is to propose a new method to quantify radioactivity with PET/CT imaging in mandibular extension in head and neck squamous cell carcinoma (HNSCC), using innovative software, and to compare results with microscopic surgical specimens. PATIENTS ANDMETHODS:
This prospective study enrolled 15 patients who underwent 18F-NaF and 18F-FDG PET/CT. We compared the delineations of bone invasions obtained with 18F-NaF PET/CT and 18F-FDG PET/CT with the results of histopathological analysis of mandibular resections (from right and left bone borders). A method for visualization and quantification of PET images was developed.RESULTS:
For all patients, a significant difference (p = 0.032 for right limits and p = 0.011 for left limits) was observed between 18F-FDG PET/CT imaging and histopathology results, and no significant difference (p = 0.88 for right limits and p = 0.55 for left limits) was observed between 18F-NaF PET/CT imaging and histopathology results. The right limits were less than 10 mm in 93% of patients, and the left limits were less than 10 mm in 86% of patients.CONCLUSIONS:
The dedicated software enabled the objective delineation of radioactivity within the bone. We can confirm that 18F-NaF is a precise and specific bone marker for the assessment of intraosseous mandibular extensions of head and neck cancers. CLINICAL QUESTION/LEVEL OF EVIDENCE Therapeutic, III.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sodium Fluoride
/
Fluorine Radioisotopes
/
Carcinoma, Squamous Cell
/
Radiopharmaceuticals
/
Positron-Emission Tomography
/
Head and Neck Neoplasms
/
Mandible
Type of study:
Observational_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Craniomaxillofac Surg
Journal subject:
ODONTOLOGIA
Year:
2017
Document type:
Article