Enhanced expression of natriuretic peptide receptor A and B in neutrophils of culprit lesions in patients with acute myocardial infarction.
Mol Med Rep
; 16(3): 3324-3330, 2017 Sep.
Article
in En
| MEDLINE
| ID: mdl-28765884
ABSTRACT
Natriuretic peptides and their specific receptors have been suggested to have regulatory effects on smooth muscle cell (SMC) growth and inflammatory cell reactions. However, the roles of natriuretic peptide receptor A (NPRA) and B (NPRB) in unstable plaques remain to be studied in detail. Frozen sections from 82 coronary artery segments were used. These segments were obtained at autopsy from 13 patients with acute myocardial infarction (AMI; 7 ruptured and 6 eroded plaques) and from 30 patients with noncardiovascular diseases. Antibodies against SMCs, endothelial cells, macrophages, neutrophils, NPRA, NPRB and neutral endopeptidase (NEP) were used. Neutrophil infiltration was identified in all lesions with plaque rupture or erosion. Double immunostaining identified that the majority of NPRA or NPRBpositive cells were neutrophils in ruptured and eroded plaques. Using morphometric analysis, no significant difference was observed in the percentage of NPRA and NPRBpositive cells between ruptured and eroded plaques, while the number of NEPpositive neutrophils in ruptured plaques was significantly higher compared with eroded plaques (P<0.0001). These results of the distinct presence of NPRA and NPRBpositive cells in unstable plaques underlying AMI suggested that natriuretic peptides serve a role in regulating plaque instability in humans.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Expression Regulation
/
Receptors, Atrial Natriuretic Factor
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Myocardial Infarction
/
Neutrophils
Type of study:
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Mol Med Rep
Year:
2017
Document type:
Article
Affiliation country:
Japan