Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells.
J Neuroimmunol
; 310: 51-59, 2017 09 15.
Article
in En
| MEDLINE
| ID: mdl-28778445
ABSTRACT
Sex hormones promote immunoregulatory effects on multiple sclerosis. In the current study we evaluated the composition of the gut microbiota and the mucosal-associated regulatory cells in estrogen or sham treated female mice before and after autoimmune encephalomyelitis (EAE) induction. Treatment with pregnancy levels of estrogen induces changes in the composition and diversity of gut microbiota. Additionally, estrogen prevents EAE-associated changes in the gut microbiota and might promote the enrichment of bacteria that are associated with immune regulation. Our results point to a possible cross-talk between the sex hormones and the gut microbiota, which could promote neuroprotection.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Encephalomyelitis, Autoimmune, Experimental
/
Estrogens
/
Microbiota
/
Intestines
/
Mucous Membrane
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
J Neuroimmunol
Year:
2017
Document type:
Article
Affiliation country:
United States